A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis
نویسندگان
چکیده
منابع مشابه
Is human dectin-1 Y238X gene polymorphism related to susceptibility to recurrent vulvovaginal candidiasis?
Background and Purpose: Vulvovaginal candidiasis is a frequent disease affecting approximately more than %75 of all childbearing women at least once in their lifetime by overgrowth of opportunistic Candida species. Recurrent vulvovaginal candidiasis (RVVC) is common in otherwise healthy individuals. Several risk factors were reported to contribute to RVVC susceptibility. A polymorphism in Decti...
متن کاملEvidence-Based Management of Recurrent Vulvovaginal Candidiasis
Vulvo-vaginal candidiasis (VVC) is a common infection among women. 5-8% of women with acute infection experience recurrent vulvo-vaginal candidiasis (RVVC). There is currently no gold standard treatment for RVVC. Although antifungal agents such as imidazoles have been successfully used as first-line treatment for acute VVC, the effectiveness of these medications is limited for RVVC, and various...
متن کاملProbiotics for prevention of recurrent vulvovaginal candidiasis: a review.
Vulvovaginal candidiasis (VVC) is a common infection affecting the quality of life of many women. Probiotics have been investigated as possible agents for the prevention of recurrences of VVC. We reviewed the available literature. In some studies the development of VVC was associated with either a low number of lactobacilli in the vagina or with the presence of H2O2-non-producing vaginal lactob...
متن کاملThe Recurrent Vulvovaginal Candidiasis: Proposal of a Personalized Therapeutic Protocol
Background. Recurrent vulvovaginal candidiasis (RVC) is an increasing challenge in clinical practice. Objective. The purpose of this study was to reduce the episodes of RVC through the intake of fluconazole 200 mg/dose with a personalized regimen at growing administration intervals with a probiotic. Method. 55 patients received a 200 mg fluconazole as an induction dose for 3 alternate days. Sym...
متن کاملGene polymorphisms in pattern recognition receptors and susceptibility to idiopathic recurrent vulvovaginal candidiasis
OBJECTIVE Approximately 5% of women suffer from recurrent vulvovaginal candidiasis (RVVC). It has been hypothesized that genetic factors play an important role in the susceptibility to RVVC. The aim of this study was to assess the effect of genetic variants of genes encoding for pattern recognition receptors (PRRs) on susceptibility to RVVC. STUDY DESIGN For the study, 119 RVVC patients and 2...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2019
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.aar3558